This is what Pfizer’s Covid-19 vaccine

This is what Pfizer’s Covid-19 vaccine

N Melo
by N Melo
December 16, 2020 0

This is what Pfizer’s Covid-19 vaccine

Knowing the composition of a vaccine is not only a matter of transparency but is also necessary for people with allergies. Here is the list of ingredients for Pfizer’s vaccine, which is not recommended in the UK for patients with a “significant” allergic history.

The content of Pfizer’s vaccine , complicated for laymen, has been deciphered by the Futura Sciences portal. Here is the list of its ingredients, available on the website of the United States Food and Drug Administration (FDA).

Active subtances
MRNA
Temporary copy of a DNA fragment of the SARS-Cov-2 Spike protein. After injection, messenger RNA is synthesized in the body, which triggers an immune response and the production of antibodies to the coronavirus. Once read, the mRNA is removed and does not integrate into our DNA.

Lipids
Lipids are used to wrap mRNA when it is injected, which prevents its destruction. In the case of Pfizer’s vaccine, the lipid ALC-0315 is used above all. Positively charged, it easily binds to mRNA, which is negatively charged. Other lipids are also used. In addition to ensuring the integrity of the envelope, they give it a white to off-white appearance.

Salts
Among four kinds of salt contained in the vaccine is “common table salt” (sodium chloride), continues the portal. Usual for vaccines, they are supposed to bring the pH of the drug closer to the natural pH of the human body. Pfizer’s vaccine thus comprises dibasic sodium phosphate dihydrate, monobasic potassium phosphate, potassium chloride, sodium chloride.

Sugar and water
Finally, the vaccine also contains sugar which acts as a preservative to prevent the nanoparticles from sticking together and protects them during freezing. Water is needed for injection.

The side effects are linked to the active ingredient of the vaccine and show that it provokes an immune response, Futura Sciences also specifies.

Allergic people
Serious side effects were reported in 0.6% of trial participants after administration of the vaccine developed by the US laboratory Pfizer and its German partner BioNTech. The most common among them were appendicitis (0.04%), heart attack (0.02%), and stroke (0.02%). There have been four cases of facial paralysis.

While the United States granted emergency clearance for the vaccine in question on December 11, the British Medicines and Health Products Regulatory Agency (MHRA) advised against it for individuals with a history of allergic reactions ” significant ”. The UK had previously acted as a pioneer in allowing it.

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